Is it possible to gain muscle mass in a calorie deficit?

I - It is possible to gain muscle mass in a calorie deficit, but it is more difficult.

II - The gain of lean tissue (muscle) is achieved only at the expense of the energy provided by the catabolism of adipose tissue (energy reserve).

III - It is necessary to signal an increase in muscle protein synthesis, such as weight training and/or the use of anabolic hormones (anabolic steroids).